Farmacologia Clinica e Traslazionale

Descrizione

Obiettivo complessivo

La Farmacologia Clinica e Traslazionale presso l’Istituto IRCCS Medea mira a rinforzare la qualità delle terapie farmacologiche, agendo in sinergia con i clinici e, nel fare questo, occupandosi anche di specifici ambiti di ricerca. La complessità e la rarità delle patologie trattate presso l’Istituto e  la tipologia di terapie loro associate, con aspetti di politerapia di farmaci in utilizzo off label, è un aspetto critico. In aggiunta, la maggioranza dei pazienti sono bambini e adolescenti, una popolazione per cui le informazioni riguardo a farmacodinamica, farmacocinetica e metabolismo sono carenti o assenti, portando spesso a difficoltà rilevanti nella definizione di terapie e dosi appropriate.Operiamo attraverso una combinazione di attività sinergiche per perseguire il nostro obiettivo. Attività di Farmacologia ClinicaLa Farmacovigilanza, che consiste nell’identificazione, segnalazione e analisi di possibili reazioni averse a farmaci, allo scopo di migliorare il rapporto rischio-beneficio complessivo delle terapie farmacologiche (per maggiori informazioni, vedere: https://www.webcounseling.it/medea1/index.php?option=com_content&view=category&layout=blog&id=29&Itemid=87). 

La Farmacocinetica e la Farmacogenetica, tramite cui la misurazione delle concentrazioni effettive di farmaco è combinata con la valutazione di specifici polimorfismi, laddove necessario, in collaborazione con l’Ospedale Luigi Sacco di Milano.

La consulenza farmacologica, che comprende sia informazione sia formazione, allo scopo di fornire aggiornamenti costanti sul profilo d’uso dei farmaci utilizzati presso l’Istituto.

Attività di Ricerca Traslazionale

• Antipsicotici e tollerabilità a lungo termine in pazienti pediatrici. Gli antipsicotici sono largamente usati in bambini e adolescenti; le informazioni disponibili sono scarse e l’uso off-label è parte della pratica clinica. Un aspetto critico è l’alterazione del metabolismo energetico associata all’uso a lungo termine di questi farmaci. Investighiamo i determinanti della risposta individuale agli antipsicotici, inclusi I livelli plasmatici e I tratti farmacogenetici allo scopo di definire marcatori biologici di sicurezza ed efficacia.
• Uso di farmaci in pazienti neurologici. La diagnosi e la terapia delle crisi neurovegetative, una condizione di eccessiva attivazione simpatica che può portare ad un peggioramento della prognosi e ad un aumento della mortalità, sono attualmente oggetto di dibattito e non esistono linee guida per il trattamento nell’età pediatrica. Il trattamento, anche con farmaci d’uso comune (ad esempio procinetici, miorilassanti), di questi pazienti può portare a conseguenze non prevedibili, con differenze significative rispetto a quanto si osserva nella popolazione generale. Le terapie antispastiche e del dolore in somministrazione intratecale, che implica effetti spesso differenti da quelli attesi per la somministrazione orale, in termini di Potenza e di stimolazione di meccanismi altrimenti non coinvolti. Questo comprende la possibilità di scoprire nuove interazioni farmacologiche e nuovi effetti. 

Analizziamo le strategie terapeutiche utilizzate presso l’Istituto, per definire marcatori biologici di efficacia appropriate, che possano orientare la scelta delle terapie o delle combinazioni migliori.

• Riposizionamento di farmaci
• In collaborazione anche con il gruppo che lavora su modelli di malattia in drosophila stiamo sviluppando nuove applicazioni per farmaci anziani, essenzialmente quelli a brevetto scaduto. Abbiamo iniziato con il riposizionamento di una combinazione di farmaci antiinfiammatori non steroidei e donatori di NO nella distrofia muscolare di Duchenne. Stiamo ora espandendo questo tipo di studi ad altre malattie rare, attraverso una varietà di approcci in vitro e in vivo.

Pubblicazioni rilevanti dal 2015

• Carnovale C, Damavandi PT, Gentili M, Pozzi M, Antoniazzi S, Radice S, Clementi E. On the association between human papillomavirus vaccine and sleep disorders: Evaluation based on vaccine adverse events Pogliani L, Baldelli S, Cattaneo D, Pileri P, Clementi E, Cetin I, Gianvincenzo Zuccotti MD. Selective serotonin reuptake inhibitors passage into human milk of lactating women. J Matern Fetal Neonatal Med. 2018 Mar 20:1-11. doi: 10.1080/14767058.2018.1455180. [Epub ahead of print] PubMed PMID: 29557689.
• Carnovale C, Raschi E, Leonardi L, Moretti U, De Ponti F, Gentili M, Pozzi M,  Clementi E, Poluzzi E, Radice S. No signal of interactions between influenza vaccines and drugs used for chronic diseases: a case-by-case analysis of the vaccine adverse event reporting system and vigibase. Expert Rev Vaccines. 2018 Mar 9:1-19. doi: 10.1080/14760584.2018.1442718. [Epub ahead of print] PubMed PMID: 29452497.
• Colella E, Cattaneo D, Galli L, Baldelli S, Clementi E, Galli M, Lazzarin A, Castagna A, Rusconi S, Spagnuolo V. Potential associations between atazanavir exposure and clinical outcome: a pharmacokinetic sub-study from the MODAt randomized trial. New Microbiol. 2018 Mar 2;41(1). [Epub ahead of print] PubMed PMID: 29498742.
• Najafi M, Cheki M, Rezapoor S, Geraily G, Motevaseli E, Carnovale C, Clementi  E, Shirazi A. Metformin: Prevention of genomic instability and cancer: A review.  Mutat Res. 2018 Mar;827:1-8. doi: 10.1016/j.mrgentox.2018.01.007. Epub 2018 Jan 31. PubMed PMID: 29502733.
• Willmann R, Buccella F, De Luca A, Grounds MD; et al., 227th ENMC workshop study group. 227(th) ENMC International Workshop:: Finalizing a plan to guarantee quality in translational research for neuromuscular diseases Heemskerk, Netherlands, 10-11 February 2017. Neuromuscul Disord. 2018 Feb;28(2):185-192. doi: 10.1016/j.nmd.2017.11.002. Epub 2017 Nov 15. PubMed PMID: 29361397.
• Castoldi S, Cozzi V, Baldelli S, Fucile S, Clementi E, Cattaneo D. Comparison  of the ARK Immunoassay With High-Performance Liquid Chromatography With Ultraviolet Detection for Therapeutic Drug Monitoring of Linezolid. Ther Drug Monit. 2018 Feb;40(1):140-143. doi: 10.1097/FTD.0000000000000473. PubMed PMID: 29324625
• Cattaneo D, Minisci D, Baldelli S, Mazzali C, Giacomelli A, Milazzo L, Meraviglia P, Resnati C, Rizzardini G, Clementi E, Galli M, Gervasoni C. Effect of Cobicistat on Tenofovir Disoproxil Fumarate (TDF): What Is True for TAF May Also Be True for TDF. J Acquir Immune Defic Syndr. 2018 Jan 1;77(1):86-92. doi: 10.1097/QAI.0000000000001558. PubMed PMID: 28961682.
• Pisano S, Pozzi M, Catone G, Scrinzi G, Clementi E, Coppola G, Milone A, Bravaccio C, Santosh P, Masi G. Putative mechanisms of action and clinical use of lithium in children and adolescents: a critical review. Curr Neuropharmacol. 2017 Dec 19. doi: 10.2174/1570159X16666171219142120. [Epub ahead of print] PubMed PMID: 29256353
• Formica F, Pozzi M, Avantaggiato P, Molteni E, Arrigoni F, Giordano F, Clementi E, Strazzer S. Disordered Consciousness or Disordered Wakefulness? The Importance of Prolonged Polysomnography for the Diagnosis, Drug Therapy, and Rehabilitation of an Unresponsive Patient With Brain Injury. J Clin Sleep Med. 2017 Dec 15;13(12):1477-1481. doi: 10.5664/jcsm.6854. PubMed PMID: 29065962; PubMed Central PMCID: PMC5695996
• Carnovale C, Gentili M, Antoniazzi S, Clementi E, Radice S. Levetiracetam-induced rhabdomyolysis: Analysis of reports from the Food and Drug  Administration's Adverse Event Reporting System database. Muscle Nerve. 2017 Dec; 56(6):E176-E178. doi: 10.1002/mus.25972. Epub 2017 Sep 30. PubMed PMID: 28888059
• Baldelli S, Clementi E, Cattaneo D. Can We Rely on AGNP Therapeutic Targets Also For LAI Antipsychotics? Pharmacopsychiatry. 2017 Nov 27. doi: 10.1055/s-0043-122603. [Epub ahead of print] PubMed PMID: 29179228.
• Pozzi M, Galbiati S, Locatelli F, Clementi E, Strazzer S. Performance of a tracheostomy removal protocol for pediatric patients in rehabilitation after acquired brain injury: Factors associated with timing and possibility of decannulation. Pediatr Pulmonol. 2017 Nov;52(11):1509-1517. doi: 10.1002/ppul.23832. Epub 2017 Sep 26. PubMed PMID: 28950420.
• Rovera C, Esposito CM, Ciappolino V, Cattaneo D, Baldelli S, Clementi E, Altamura AC, Buoli M. Quetiapine-Induced Hypomania and its Association with Quetiapine/Norquetiapine Plasma Concentrations: A Case Series of Bipolar Type 2 Patients. Drug Saf Case Rep. 2017 Oct 23;4(1):13. doi: 10.1007/s40800-017-0057-9. PubMed PMID: 29063217; PubMed Central PMCID: PMC5653679.
• Baldelli S, Marrubini G, Cattaneo D, Clementi E, Cerea M. Application of Quality by Design Approach to Bioanalysis: Development of a Method for Elvitegravir Quantification in Human Plasma. Ther Drug Monit. 2017 Oct;39(5):531-542. doi: 10.1097/FTD.0000000000000428. PubMed PMID: 28650901.
• Carnovale C, Damavandi PT, Gentili M, Pozzi M, Antoniazzi S, Radice S, Clementi E. On the association between human papillomavirus vaccine and sleep disorders: Evaluation based on vaccine adverse events reporting systems. J Neurol Sci. 2017 Sep 15;380:275-276. doi: 10.1016/j.jns.2017.07.051. Epub 2017 Aug 4. PubMed PMID: 28803636.
• Rafaniello C, Sessa M, Bernardi FF, Pozzi M, Cheli S, Cattaneo D, Baldelli S,  Molteni M, Bernardini R, Rossi F, Clementi E, Bravaccio C, Radice S, Capuano A. The predictive value of ABCB1, ABCG2, CYP3A4/5 and CYP2D6 polymorphisms for risperidone and aripiprazole plasma concentrations and the occurrence of adverse  drug reactions. Pharmacogenomics J. 2017 Jul 18. doi: 10.1038/tpj.2017.38. [Epub  ahead of print] PubMed PMID: 28719598.
• Carnovale C, Russo S, Biondelli G, Gentili M, Pozzi M, Antoniazzi S, Radice S, Clementi E. Levocetirizine-induced Psychiatric Disorders in a Pediatric Patient:  A Case Report and a Pharmacovigilance Database Analysis. J Pharmacol Pharmacother. 2017 Apr-Jun;8(2):74-76. doi: 10.4103/jpp.JPP_14_17. PubMed PMID: 28706402; PubMed Central PMCID: PMC5497403.
• Baldelli S, Marrubini G, Cattaneo D, Clementi E, Cerea M. Application Of Quality By Design Approach To Bioanalysis: Development Of A Method For Elvitegravir Quantification In Human Plasma. Ther Drug Monit. 2017 Jun 22. doi: 10.1097/FTD.0000000000000428. [Epub ahead of print] PubMed PMID: 28650901
• Salvaggio SE, Giacomelli A, Falvella FS, Oreni ML, Meraviglia P, Atzori C, Clementi EGI, Galli M, Rusconi S. Clinical and genetic factors associated with kidney tubular dysfunction in a real-life single centre cohort of HIV-positive patients. BMC Infect Dis. 2017 Jun 5;17(1):396. doi: 10.1186/s12879-017-2497-3. PubMed PMID: 28583112; PubMed Central PMCID: PMC5460416.
• Antoniazzi S, Carnovale C, Sessa A, Gentili M, Matacena M, Punginelli M, Clementi E, Radice S. Auditory and visual hallucinations after influenza vaccine: a case report. Ther Adv Vaccines. 2017 Feb;5(1):25-27. doi: 10.1177/2051013616673554. Epub 2016 Oct 21. PubMed PMID: 28344806; PubMed Central PMCID: PMC5349333.
• Rovera C, Mauri MC, Chiara DP, Paletta S, Reggiori A, Ciappolino V, Cattaneo D, Baldelli S, Clementi E, Altamura AC. Effect of N-Desalkylquetiapine/Quetiapine Plasma Level Ratio on Anxiety and Depression in Bipolar Disoder: A Prospective Observational Study. Ther Drug Monit. 2017 Aug;39(4):441-445. doi: 10.1097/FTD.0000000000000413. PubMed PMID: 28486308.
• Gervasoni C, Riva A, Cozzi V, Capetti A, Rizzardini G, Clementi E, Cattaneo D. Effects of ritonavir and cobicistat on dolutegravir exposure: when the booster can make the difference. J Antimicrob Chemother. 2017 Jun 1;72(6):1842-1844. doi: 10.1093/jac/dkx055. PubMed PMID: 28333266.
• Carnovale C, Damavandi PT, Gentili M, Pozzi M, Antoniazzi S, Radice S, Clementi E. On the association between human papillomavirus vaccine and sleep disorders: Evaluation based on vaccine adverse events reporting systems. J Neurol Sci. 2017 Feb 15;373:179-181. doi: 10.1016/j.jns.2016.12.067. Epub 2016 Dec 29. PubMed PMID: 28131183.
• Gervasoni C, Minisci D, Clementi E, Rizzardini G, Cattaneo D. How Relevant is the Interaction Between Dolutegravir and Metformin in Real Life? J Acquir Immune  Defic Syndr. 2017 May 1;75(1):e24-e26. doi: 10.1097/QAI.0000000000001292. PubMed  PMID: 28114188.
• Falvella FS, Cheli S, Clementi E. HLA-B*57. Pharmacogenet Genomics. 2017 Feb;27(2):81-82. doi: 10.1097/FPC.0000000000000258. PubMed PMID: 28059981.
• Pogliani L, Falvella FS, Cattaneo D, Pileri P, Moscatiello AF, Cheli S, Baldelli S, Fabiano V, Cetin I, Clementi E, Zuccotti G. Pharmacokinetics and Pharmacogenetics of Selective Serotonin Reuptake Inhibitors During Pregnancy: An  Observational Study. Ther Drug Monit. 2017 Apr;39(2):197-201. doi: 10.1097/FTD.0000000000000370. PubMed PMID: 28045861.
• Cattaneo D, Minisci D, Cozzi V, Riva A, Meraviglia P, Clementi E, Galli M, Gervasoni C. Dolutegravir plasma concentrations according to companion antiretroviral drug: unwanted drug interaction or desirable boosting effect? Antivir Ther. 2016 Dec 23. doi: 10.3851/IMP3119. [Epub ahead of print] PubMed PMID: 28008867.
• Pambianco S, Giovarelli M, Perrotta C, Zecchini S, Cervia D, Di Renzo I, Moscheni C, Ripolone M, Violano R, Moggio M, Bassi MT, Puri PL, Latella L, Clementi E, De Palma C. Reversal of Defective Mitochondrial Biogenesis in Limb-Girdle Muscular Dystrophy 2D by Independent Modulation of Histone and PGC-1α Acetylation. Cell Rep. 2016 Dec 13;17(11):3010-3023. doi: 10.1016/j.celrep.2016.11.044. PubMed PMID: 27974213.
• Carnovale C, Gentili M, Matacena M, Dimov Di Giusti M, Krnic D, Dolinic B, Kolaric D, Margan Koletic Z, Macolic Sarinic V, Culjak M, Fortino I, Merlino L, Clementi E, Radice S. A retrospective review of paediatric adverse drug reactions reported in Lombardy and Croatia from 2005 to 2013. Expert Opin Drug Saf. 2016 Dec;15(sup2):35-43. PubMed PMID: 27875921.
• Rafaniello C, Pozzi M, Pisano S, Ferrajolo C, Bertella S, Sportiello L, Carnovale C, Sullo MG, Cattaneo D, Gentili M, Rizzo R, Pascotto A, Mani E, Villa  L, Riccio MP, Sperandeo S, Bernardini R, Bravaccio C, Clementi E, Molteni M, Rossi F, Radice S, Capuano A. Second generation antipsychotics in 'real-life' paediatric patients. Adverse drug reactions and clinical outcomes of drug switch. Expert Opin Drug Saf. 2016 Dec;15(sup2):1-8. PubMed PMID: 27875914.
• Baldelli S, Cattaneo D, Cerea M, Pignatelli P, Violi F, Clementi E. Identification of Different Patterns of Dabigatran In Vivo Bioactivation in Patients on Maintenance Anticoagulation Therapy. Ther Drug Monit. 2016 Dec;38(6):814-816. PubMed PMID: 27855135.
• Pozzi M, Pineschi R, Bonanni P, Pellegri A, Clementi E. Precipitation of Carbamazepine-Controlled Seizures Due to Low-Dose Risperidone in a Child: A Conspiracy to Unbalance Blood Electrolytes. J Clin Psychopharmacol. 2016 Dec;36(6):729-730. PubMed PMID: 27680767.
• Antoniazzi S, Tatulli A, Falvella FS, Cigliobianco M, Paoli RA, Cattaneo D, Cheli S, Bernardi FF, Clementi E, Altamura CA. The combination of pharmacogenetic and pharmacokinetic analyses to optimize clomipramine dosing in major depression: a case report. J Clin Pharm Ther. 2017 Feb;42(1):119-121. doi: 10.1111/jcpt.12478. Epub 2016 Oct 31. PubMed PMID: 27800629.
• Pozzi M, Pisano S, Bertella S, Capuano A, Rizzo R, Antoniazzi S, Auricchio F, Carnovale C, Cattaneo D, Ferrajolo C, Gentili M, Guastella G, Mani E, Rafaniello  C, Riccio MP, Scuderi MG, Sperandeo S, Sportiello L, Villa L, Radice S, Clementi  E, Rossi F, Pascotto A, Bernardini R, Molteni M, Bravaccio C. Persistence in Therapy With Risperidone and Aripiprazole in Pediatric Outpatients: A 2-Year Naturalistic Comparison. J Clin Psychiatry. 2016 Dec;77(12):e1601-e1609. doi: 10.4088/JCP.15m10247. PubMed PMID: 27780333.
• Cattaneo D, Gervasoni C, Cozzi V, Castoldi S, Baldelli S, Clementi E. Therapeutic drug management of linezolid: a missed opportunity for clinicians? Int J Antimicrob Agents. 2016 Dec;48(6):728-731. doi: 10.1016/j.ijantimicag.2016.08.023. Epub 2016 Oct 12. PubMed PMID: 27769709.
• Pozzi M, Conti V, Locatelli F, Galbiati S, Radice S, Clementi E, Strazzer S.  Paroxysmal Sympathetic Hyperactivity in Pediatric Rehabilitation: Pathological Features and Scheduled Pharmacological Therapies. J Head Trauma Rehabil. 2017 Mar/Apr;32(2):117-124. doi: 10.1097/HTR.0000000000000255. PubMed PMID: 27603764.
• Cattaneo D, Baldelli S, Minisci D, Meraviglia P, Clementi E, Galli M, Gervasoni C. When food can make the difference: The case of elvitegravir-based co-formulation. Int J Pharm. 2016 Oct 15;512(1):301-4. doi: 10.1016/j.ijpharm.2016.08.063. Epub 2016 Aug 31. PubMed PMID: 27592195.
• Palmieri B, Poddighe D, Vadalà M, Laurino C, Carnovale C, Clementi E. Severe  somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature. Immunol Res. 2017 Feb;65(1):106-116. doi: 10.1007/s12026-016-8820-z. Erratum in: Immunol Res. 2017 Feb;65(1):117-119. PubMed PMID: 27503625; PubMed Central PMCID: PMC5406435.
• Gentili M, Magni C, Carnovale C, Bolis M, Landonio S, Niero F, Antoniazzi S,  Clementi E, Radice S. Breast Hypertrophy Induced by Ombitasvir/Paritaprevir/Ritonavir and Ribavirina. Breast J. 2016 Nov;22(6):708-709. doi: 10.1111/tbj.12656. Epub 2016 Aug 4. PubMed PMID: 27488453.
• Falvella FS, Marelli S, Cheli S, Montanelli S, Viecca F, Salvi L, Ferrara A,  Clementi E, Trifirò G, Pini A. Pharmacogenetic approach to losartan in Marfan patients: a starting point to improve dosing regimen? Drug Metab Pers Ther. 2016  Sep 1;31(3):157-63. doi: 10.1515/dmpt-2016-0006. PubMed PMID: 27474842.
• Perrotta C, Buonanno F, Zecchini S, Giavazzi A, Proietti Serafini F, Catalani E, Guerra L, Belardinelli MC, Picchietti S, Fausto AM, Giorgi S, Marcantoni E, Clementi E, Ortenzi C, Cervia D. Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent intrinsic apoptotic programme. Sci  Rep. 2016 Jun 7;6:27281. doi: 10.1038/srep27281. PubMed PMID: 27271364; PubMed Central PMCID: PMC4895139.
• Gervasoni C, Minisci D, Meraviglia P, Baldelli S, Clementi E, Rizzardini G, Cattaneo D. Determinants of bone diseases in tenofovir-treated HIV patients. AIDS. 2016 Jun 19;30(10):1686-7. doi: 10.1097/QAD.0000000000001094. PubMed PMID:  27243779.
• Pisano S, Catone G, Veltri S, Lanzara V, Pozzi M, Clementi E, Iuliano R, Riccio MP, Radice S, Molteni M, Capuano A, Gritti A, Coppola G, Milone A, Bravaccio C, Masi G. Update on the safety of second generation antipsychotics in youths: a call for collaboration among paediatricians and child psychiatrists. Ital J Pediatr. 2016 May 21;42(1):51. doi: 10.1186/s13052-016-0259-2. Review. PubMed PMID: 27209326; PubMed Central PMCID: PMC4875613.
• Cervia D, Assi E, De Palma C, Giovarelli M, Bizzozero L, Pambianco S, Di Renzo I, Zecchini S, Moscheni C, Vantaggiato C, Procacci P, Clementi E, Perrotta  C. Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin. Oncotarget. 2016 May 3;7(18):24995-5009. doi: 10.18632/oncotarget.8735. PubMed PMID: 27107419; PubMed Central PMCID: PMC5041885.
• Cattaneo D, Gervasoni C, Clementi E. Is there still room for therapeutic drug monitoring of linezolid in patients with tuberculosis? Eur Respir J. 2016 Apr;47(4):1287-8. doi: 10.1183/13993003.01913-2015. PubMed PMID: 27037318.
• Falvella FS, Cremolini C, Miceli R, Nichetti F, Cheli S, Antoniotti C, Infante G, Martinetti A, Marmorino F, Sottotetti E, Berenato R, Caporale M, Colombo A, de Braud F, Di Bartolomeo M, Clementi E, Loupakis F, Pietrantonio F. Variant alleles in factor V, prothrombin, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase and risk of thromboembolism in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab. Pharmacogenomics J. 2017 Jul;17(4):331-336. doi: 10.1038/tpj.2016.22. Epub 2016 Mar 22. PubMed PMID: 27001121.
• Gervasoni C, Cattaneo D, Di Cristo V, Castoldi S, Gervasi E, Clementi E, Riva A. Orlistat: weight lost at cost of HIV rebound. J Antimicrob Chemother. 2016 Jun;71(6):1739-41. doi: 10.1093/jac/dkw033. Epub 2016 Mar 5. PubMed PMID: 26945709.
• Cattaneo D, Riva A, Clementi E, Milazzo L, Gervasoni C. Severe Hyperbilirubinemia in an HIV-HCV-Coinfected Patient Starting the 3D Regimen That  Resolved After TDM-Guided Atazanavir Dose Reduction. Ther Drug Monit. 2016 Jun;38(3):285-7. doi: 10.1097/FTD.0000000000000293. PubMed PMID: 26919548.
• Strazzer S, Pozzi M, Avantaggiato P, Zanotta N, Epifanio R, Beretta E, Formica F, Locatelli F, Galbiati S, Clementi E, Zucca C. Late Post-traumatic Epilepsy in Children and Young Adults: Impropriety of Long-Term Antiepileptic Prophylaxis and Risks in Tapering. Paediatr Drugs. 2016 Jun;18(3):235-42. doi: 10.1007/s40272-016-0167-3. PubMed PMID: 26913859.
• Cozzi V, Charbe N, Baldelli S, Castoldi S, Atzori C, Cattaneo D, Clementi E.  Development and Validation of a Chromatographic Ultraviolet Method for the Simultaneous Quantification of Dolutegravir and Rilpivirine in Human Plasma. Ther Drug Monit. 2016 Jun;38(3):407-13. doi: 10.1097/FTD.0000000000000290. PubMed PMID: 26885814.
• Carnovale C, Gentili M, Fortino I, Merlino L, Clementi E, Radice S, ViGer Group. The importance of monitoring adverse drug reactions in elderly patients: the results of a long-term pharmacovigilance programme. Expert Opin Drug Saf. 2016;15(2):131-9. doi: 10.1517/14740338.2016.1131816. PubMed PMID: 26882049.
• Carnovale C, Gentili M, Antoniazzi S, Radice S, Clementi E. Montelukast-induced metamorphopsia in a pediatric patient: A case report and a pharmacovigilance database analysis. Ann Allergy Asthma Immunol. 2016 Apr;116(4):370-1. doi: 10.1016/j.anai.2016.01.013. Epub 2016 Feb 10. Review. PubMed PMID: 26874930.
• Baldelli S, Cattaneo D, Pignatelli P, Perrone V, Pastori D, Radice S, Violi F, Clementi E. Validation of an LC-MS/MS method for the simultaneous quantification of dabigatran, rivaroxaban and apixaban in human plasma. Bioanalysis. 2016 Feb;8(4):275-83. doi: 10.4155/bio.15.261. Epub 2016 Jan 25. PubMed PMID: 26808218.
• Gentili M, Marinaccio PM, Galimberti C, Carnovale C, Antoniazzi S, Pozzi M, Clementi E, Viganò C, Radice S. A case of dysgraphia induced by sertraline and a  review of official spontaneous adverse reaction databases. J Clin Pharm Ther. 2016 Feb;41(1):106-7. doi: 10.1111/jcpt.12356. Epub 2016 Jan 21. PubMed PMID: 26792111.
• Cattaneo D, Puoti M, Sollima S, Moioli C, Foppa CU, Baldelli S, Clementi E, Gervasoni C. Reduced raltegravir clearance in HIV-infected liver transplant recipients: an unexpected interaction with immunosuppressive therapy? J Antimicrob Chemother. 2016 May;71(5):1341-5. doi: 10.1093/jac/dkv466. Epub 2016 Jan 10. PubMed PMID: 26755497.
• Pozzi M, Radice S, Clementi E, Molteni M, Nobile M. Antidepressants and, suicide and self-injury: Causal or casual association? Int J Psychiatry Clin Pract. 2016;20(1):47-51. doi: 10.3109/13651501.2015.1117111. Epub 2016 Jan 11. Review. PubMed PMID: 26750572.
• Gervasoni C, Baldelli S, Cerea M, Cenderello G, Bini T, Vimercati S, Iardino  R, Gazzaniga A, DʼArminio Monforte A, Clementi E, Cattaneo D. Comparison of the In Vivo Pharmacokinetics and In Vitro Dissolution of Branded Versus Generic Efavirenz Formulation in HIV-Infected Patients. Ther Drug Monit. 2016 Jun;38(3):420-2. doi: 10.1097/FTD.0000000000000273. PubMed PMID: 26727626.
• Diphoorn J, Cazzaniga S, Gamba C, Schroeder J, Citterio A, Rivolta AL, Vighi  GD, Naldi L; REACT-Lombardia study group. Incidence, causative factors and mortality rates of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis  (TEN) in northern Italy: data from the REACT registry. Pharmacoepidemiol Drug Saf. 2016 Feb;25(2):196-203. doi: 10.1002/pds.3937. Epub 2015 Dec 21. PubMed PMID: 26687641.
• Pozzi M, Cattaneo D, Baldelli S, Fucile S, Capuano A, Bravaccio C, Sportiello L, Bertella S, Auricchio F, Bernardini R, Ferrajolo C, Guastella G, Mani E, Carnovale C, Pisano S, Rafaniello C, Riccio MP, Rizzo R, Scuderi MG, Sperandeo S, Villa L, Pascotto A, Molteni M, Rossi F, Radice S, Clementi E. Therapeutic drug monitoring of second-generation antipsychotics in pediatric patients: an observational study in real-life settings. Eur J Clin Pharmacol. 2016 Mar;72(3):285-93. doi: 10.1007/s00228-015-1982-0. Epub 2015 Nov 28. PubMed PMID:  26613956.
• Fabiano V, Carnovale C, Gentili M, Radice S, Zuccotti GV, Clementi E, Perrotta C, Mameli C. Enalapril Associated with Furosemide Induced Acute Kidney Injury in an Infant with Heart Failure. A Case Report, a Revision of the Literature and a Pharmacovigilance Database Analysis. Pharmacology. 2016;97(1-2):38-42. doi: 10.1159/000441950. Epub 2015 Nov 18. PubMed PMID: 26575260.
• Marano M, Bottaro G, Goffredo B, Stoppa F, Pisani M, Marinaro AM, Deodato F,  Dionisi-Vici C, Clementi E, Falvella FS. Deferasirox-induced serious adverse reaction in a pediatric patient: pharmacokinetic and pharmacogenetic analysis. Eur J Clin Pharmacol. 2016 Feb;72(2):247-8. doi: 10.1007/s00228-015-1956-2. Epub  2015 Sep 24. PubMed PMID: 26403473.
• Pozzi M, Bertella S, Molteni M, Antoniazzi S, Carnovale C, Gentili M, Pellegrino P, Perrone V, Clementi E, Radice S. Restless Sleep in a Hyperactive Girl: A Paradoxical Adverse Reaction to Methylphenidate. J Clin Psychopharmacol.  2015 Dec;35(6):738-9. doi: 10.1097/JCP.0000000000000396. PubMed PMID: 26368544.
• Cattaneo D, Sollima S, Charbe N, Resnati C, Clementi E, Gervasoni C. Suspected pharmacokinetic interaction between raltegravir and the 3D regimen of ombitasvir, dasabuvir and paritaprevir/ritonavir in an HIV-HCV liver transplant recipient. Eur J Clin Pharmacol. 2016 Mar;72(3):365-7. doi: 10.1007/s00228-015-1936-6. Epub 2015 Sep 12. PubMed PMID: 26362279.
• Miglietta D, De Palma C, Sciorati C, Vergani B, Pisa V, Villa A, Ongini E, Clementi E. Naproxcinod shows significant advantages over naproxen in the mdx model of Duchenne Muscular Dystrophy. Orphanet J Rare Dis. 2015 Aug 22;10:101. doi: 10.1186/s13023-015-0311-0. PubMed PMID: 26296873; PubMed Central PMCID: PMC4546261.
• Lombardi A, Landonio S, Magni C, Cheli S, Mazzali C, Mondelli MU, Rizzardini  G, Clementi E, Falvella FS. ITPA and SLC29A1 Genotyping for the Prediction of Ribavirin Dose Reduction in Anti-HCV Triple Therapy with Protease Inhibitors. Pharmacology. 2015;96(3-4):163-6. doi: 10.1159/000438486. Epub 2015 Aug 8. PubMed PMID: 26279293.
• Pozzi M, Locatelli F, Galbiati S, Clementi E, Strazzer S. Re: "Paroxysmal Sympathetic Hyperactivity: A New Era for Diagnosis and Treatment". J Head Trauma  Rehabil. 2015 Sep-Oct;30(5):366-7. doi: 10.1097/HTR.0000000000000115. PubMed PMID: 26348165.
• Falvella FS, Ricci E, Cheli S, Resnati C, Cozzi V, Cattaneo D, Gervasoni C, Clementi E, Galli M, Riva A. Pharmacogenetics-based optimisation of atazanavir treatment: potential role of new genetic predictors. Drug Metab Pers Ther. 2017 May 24;32(2):115-117. doi: 10.1515/dmpt-2017-0006. PubMed PMID: 28599374.
• Pellegrino P, Perrotta C, Clementi E, Radice S. Vaccine-Drug Interactions: Cytokines, Cytochromes, and Molecular Mechanisms. Drug Saf. 2015 Sep;38(9):781-7. doi: 10.1007/s40264-015-0330-8. Review. PubMed PMID: 26239715.
• Perrotta C, De Palma C, Clementi E, Cervia D. Hormones and immunity in cancer: are thyroid hormones endocrine players in the microglia/glioma cross-talk? Front Cell Neurosci. 2015 Jun 23;9:236. doi: 10.3389/fncel.2015.00236. eCollection 2015. PubMed PMID: 26157361; PubMed Central PMCID: PMC4477169.
• Gervasoni C, Bergia R, Cozzi V, Clementi E, Cattaneo D. Is it time to revise  linezolid doses in peritoneal dialysis patients? A case series. J Antimicrob Chemother. 2015 Oct;70(10):2918-20. doi: 10.1093/jac/dkv184. Epub 2015 Jul 3. PubMed PMID: 26142409.
• Assi E, Cervia D, Bizzozero L, Capobianco A, Pambianco S, Morisi F, De Palma  C, Moscheni C, Pellegrino P, Clementi E, Perrotta C. Modulation of Acid Sphingomyelinase in Melanoma Reprogrammes the Tumour Immune Microenvironment. Mediators Inflamm. 2015;2015:370482. doi: 10.1155/2015/370482. Epub 2015 May 26.  PubMed PMID: 26101462; PubMed Central PMCID: PMC4460251.
• Pozzi M, Pisano S, Bertella S, Lombardi P, Pellegrino P, Molteni M, Clementi  E, Bravaccio C, Radice S. On the Possible Relationship Between Anti-Streptolysin-O Titer and Neuropsychiatric Disorders Other than PANS. J Child Adolesc Psychopharmacol. 2015 Jun;25(5):452-3. doi: 10.1089/cap.2014.0170. PubMed PMID: 26091201.
• Cheli S, Pietrantonio F, Clementi E, Falvella FS. LightSNiP assay is a good strategy for pharmacogenetics test. Front Pharmacol. 2015 Jun 2;6:114. doi: 10.3389/fphar.2015.00114. eCollection 2015. PubMed PMID: 26082719; PubMed Central PMCID: PMC4451335.
• Pellegrino P, Radice S, Clementi E. Immunogenicity and safety of the human papillomavirus vaccine in patients with autoimmune diseases: A systematic review. Vaccine. 2015 Jul 9;33(30):3444-9. doi: 10.1016/j.vaccine.2015.05.041. Epub 2015  May 31. Review. PubMed PMID: 26036945.
• Pellegrino P, Clementi E, Radice S. On vaccine's adjuvants and autoimmunity:  Current evidence and future perspectives. Autoimmun Rev. 2015 Oct;14(10):880-8. doi: 10.1016/j.autrev.2015.05.014. Epub 2015 May 29. Review. PubMed PMID: 26031899.
• Falvella FS, Caporale M, Cheli S, Martinetti A, Berenato R, Maggi C, Niger M, Ricchini F, Bossi I, Di Bartolomeo M, Sottotetti E, Bernardi FF, de Braud F, Clementi E, Pietrantonio F. Undetected toxicity risk in pharmacogenetic testing for dihydropyrimidine dehydrogenase. Int J Mol Sci. 2015 Apr 21;16(4):8884-95. doi: 10.3390/ijms16048884. Review. PubMed PMID: 25906475; PubMed Central PMCID: PMC4425114.
• Gervasoni C, Meraviglia P, Minisci D, Ferraris L, Riva A, Landonio S, Cozzi V, Charbe N, Molinari L, Rizzardini G, Clementi E, Galli M, Cattaneo D. Metabolic and kidney disorders correlate with high atazanavir concentrations in HIV-infected patients: is it time to revise atazanavir dosages? PLoS One. 2015 Apr 15;10(4):e0123670. doi: 10.1371/journal.pone.0123670. eCollection 2015. PubMed PMID: 25875091; PubMed Central PMCID: PMC4398451.
• Sciorati C, Clementi E, Manfredi AA, Rovere-Querini P. Fat deposition and accumulation in the damaged and inflamed skeletal muscle: cellular and molecular  players. Cell Mol Life Sci. 2015 Jun;72(11):2135-56. doi: 10.1007/s00018-015-1857-7. Epub 2015 Feb 18. Review. PubMed PMID: 25854633.
• Pellegrino P, Falvella FS, Cheli S, Perrotta C, Clementi E, Radice S. The role of Toll-like receptor 4 polymorphisms in vaccine immune response. Pharmacogenomics J. 2016 Feb;16(1):96-101. doi: 10.1038/tpj.2015.21. Epub 2015 Mar 31. Review. PubMed PMID: 25823688.
• Falvella FS, Cheli S, Martinetti A, Mazzali C, Iacovelli R, Maggi C, Gariboldi M, Pierotti MA, Di Bartolomeo M, Sottotetti E, Mennitto R, Bossi I, de  Braud F, Clementi E, Pietrantonio F. DPD and UGT1A1 deficiency in colorectal cancer patients receiving triplet chemotherapy with fluoropyrimidines, oxaliplatin and irinotecan. Br J Clin Pharmacol. 2015 Sep;80(3):581-8. doi: 10.1111/bcp.12631. Epub 2015 Jun 22. PubMed PMID: 25782327; PubMed Central PMCID: PMC4574842.
• Gervasoni C, Simonetti FR, Resnati C, Charbe N, Clementi E, Cattaneo D. Prolonged inductive effect of rifampicin on linezolid exposure. Eur J Clin Pharmacol. 2015 May;71(5):643-4. doi: 10.1007/s00228-015-1833-z. Epub 2015 Mar 18. PubMed PMID: 25778934.
• Baldelli S, Castoldi S, Charbe N, Cozzi V, Fucile S, Cattaneo D, Clementi E.  Comparison of the QMS Analyzer With HPLC-UV for the Quantification of Lamotrigine Concentrations in Human Plasma Samples. Ther Drug Monit. 2015 Oct;37(5):689-94. doi: 10.1097/FTD.0000000000000202. PubMed PMID: 25730145.
• Brusadelli T, Carnovale C, Gentili M, Borsadoli C, Speziali A, Perrone V, Pellegrino P, Antoniazzi S, Pozzi M, Radice S, Clementi E. Throbbing headache associated with enoxaparin administration: a case report, a review of pharmacovigilance databases for similar cases and possible mechanisms. J Clin Pharm Ther. 2015 Jun;40(3):342-4. doi: 10.1111/jcpt.12257. Epub 2015 Mar 2. PubMed PMID: 25726970.
• Touvier T, De Palma C, Rigamonti E, Scagliola A, Incerti E, Mazelin L, Thomas JL, D'Antonio M, Politi L, Schaeffer L, Clementi E, Brunelli S. Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation. Cell Death Dis. 2015 Feb 26;6:e1663. doi: 10.1038/cddis.2014.595. PubMed PMID: 25719247; PubMed Central PMCID: PMC4669802.
• Perrotta C, Pellegrino P, Moroni E, De Palma C, Cervia D, Danelli P, Clementi E. Five-aminosalicylic Acid: an update for the reappraisal of an old drug. Gastroenterol Res Pract. 2015;2015:456895. doi: 10.1155/2015/456895. Epub 2015 Jan 21. Review. PubMed PMID: 25685145; PubMed Central PMCID: PMC4320793.
• Pozzi M, Galbiati S, Locatelli F, Granziera M, Santi M, Colombo D, Pellegrino P, Radice S, Clementi E, Strazzer S. Prevention of respiratory infections in tracheostomized patients of a pediatric long-term rehabilitation setting. Am J Infect Control. 2015 Apr 1;43(4):394-6. doi: 10.1016/j.ajic.2014.12.015. Epub 2015 Feb 8. PubMed PMID: 25672950.
• Perrotta C, Cervia D, De Palma C, Assi E, Pellegrino P, Bassi MT, Clementi E. The emerging role of acid sphingomyelinase in autophagy. Apoptosis. 2015 May;20(5):635-44. doi: 10.1007/s10495-015-1101-9. Review. PubMed PMID: 25666706.
• Gervasoni C, Terzi R, Heidempergher M, Clementi E, Cattaneo D. Linezolid-related haematological toxicity in a peritoneal dialysis patient: the role of therapeutic drug monitoring. Eur J Clin Pharmacol. 2015 Mar;71(3):383-5.  doi: 10.1007/s00228-015-1809-z. Epub 2015 Jan 22. PubMed PMID: 25604510.
• Milazzo L, Peri AM, Mazzali C, Magni C, Calvi E, De Nicolò A, Clementi E, Cheli S, D'Avolio A, Antinori S, Falvella FS. SLC29A1 polymorphism and prediction of anaemia severity in patients with chronic hepatitis C receiving triple therapy with telaprevir. J Antimicrob Chemother. 2015 Apr;70(4):1155-60. doi: 10.1093/jac/dku519. Epub 2015 Jan 11. PubMed PMID: 25583751.
• De Palma C, Morisi F, Pambianco S, Assi E, Touvier T, Russo S, Perrotta C, Romanello V, Carnio S, Cappello V, Pellegrino P, Moscheni C, Bassi MT, Sandri M,  Cervia D, Clementi E. Deficient nitric oxide signalling impairs skeletal muscle growth and performance: involvement of mitochondrial dysregulation. Skelet Muscle. 2014 Dec 12;4(1):22. doi: 10.1186/s13395-014-0022-6. eCollection 2014. PubMed PMID: 25530838; PubMed Central PMCID: PMC4272808.
• Carnovale C, Brusadelli T, Casini ML, Renda F, Ruggieri S, Pimpinella G, Radice S, Clementi E. Drug-induced anaemia: a decade review of reporting to the Italian Pharmacovigilance data-base. Int J Clin Pharm. 2015 Feb;37(1): 23-6. doi: 10.1007/s11096-014-0054-3. Epub 2014 Dec 17. Review. PubMed PMID: 25515616.
• Perrone V, Conti V, Venegoni M, Scotto S, Degli Esposti L, Sangiorgi D, Prestini L, Radice S, Clementi E, Vighi G. Seriousness, preventability, and burden impact of reported adverse drug reactions in Lombardy emergency departments: a retrospective 2-year characterization. Clinicoecon Outcomes Res. 2014 Dec 3;6:505-14. doi: 10.2147/CEOR.S71301. eCollection 2014. PubMed PMID: 25506231; PubMed Central PMCID: PMC4259870.
• Pozzi M, Piccinini L, Gallo M, Motta F, Radice S, Clementi E. Treatment of motor and behavioural symptoms in three Lesch-Nyhan patients with intrathecal baclofen. Orphanet J Rare Dis. 2014 Dec 12;9:208. doi: 10.1186/s13023-014-0208-3. PubMed PMID: 25497359; PubMed Central PMCID: PMC4266221.
• Pellegrino P, Perrone V, Radice S, Capuano A, Clementi E. Immunogenicity of meningococcal quadrivalent (serogroup A, C, W135 and Y) tetanus toxoid conjugate  vaccine: systematic review and meta-analysis. Pharmacol Res. 2015 Feb;92:31-9. doi: 10.1016/j.phrs.2014.10.006. Epub 2014 Oct 30. Review. PubMed PMID: 25447792.
• Pellegrino P, Radice S, Clementi E. Acute disseminated encephalomyelitis following influenza vaccine. Epidemiology. 2015 Jan;26(1):e12-3. doi: 10.1097/EDE.0000000000000210. PubMed PMID: 25437322.
• Cattaneo D, Baldelli S, Castoldi S, Charbe N, Cozzi V, Fucile S, Clementi E.  Is it time to revise antiretrovirals dosing? a pharmacokinetic viewpoint. AIDS. 2014 Oct 23;28(16):2477-80. PubMed PMID: 25392858.
• Cappellari AM, Cattaneo D, Clementi E, Kustermann A. Increased levetiracetam  clearance and breakthrough seizure in a pregnant patient successfully handled by  intensive therapeutic drug monitoring. Ther Drug Monit. 2015 Jun;37(3):285-7. doi: 10.1097/FTD.0000000000000144. PubMed PMID: 25384117.
• Pellegrino P, Perrone V, Pozzi M, Carnovale C, Perrotta C, Clementi E, Radice S. The epidemiological profile of ASIA syndrome after HPV vaccination: an evaluation based on the Vaccine Adverse Event Reporting Systems. Immunol Res. 2015 Feb;61(1-2):90-6. doi: 10.1007/s12026-014-8567-3. PubMed PMID: 25381482.
• Pozzi M, Conti V, Locatelli F, Galbiati S, Radice S, Citerio G, Clementi E, Strazzer S. Paroxysmal Sympathetic Hyperactivity in Pediatric Rehabilitation: Clinical Factors and Acute Pharmacological Management. J Head Trauma Rehabil. 2015 Sep-Oct;30(5):357-63. doi: 10.1097/HTR.0000000000000084. PubMed PMID: 25310291.
• Perdoni F, Falleni M, Tosi D, Cirasola D, Romagnoli S, Braidotti P, Clementi  E, Bulfamante G, Borghi E. A histological procedure to study fungal infection in  the wax moth Galleria mellonella. Eur J Histochem. 2014 Sep 23;58(3):2428. doi: 10.4081/ejh.2014.2428. PubMed PMID: 25308852; PubMed Central PMCID: PMC419400.
• Pellegrino P, Falvella FS, Perrone V, Carnovale C, Brusadelli T, Pozzi M, Antoniazzi S, Cheli S, Perrotta C, Clementi E, Radice S. The first steps towards  the era of personalised vaccinology: predicting adverse reactions. Pharmacogenomics J. 2015 Jun;15(3):284-7. doi: 10.1038/tpj.2014.57. Epub 2014 Oct 7. Review. PubMed PMID: 25287071.
• Gervasoni C, Riva A, Rizzardini G, Clementi E, Galli M, Cattaneo D. Potential association between rosuvastatin use and high atazanavir trough concentrations in ritonavir-treated HIV-infected patients. Antivir Ther. 2015;20(4):449-51. doi: 10.3851/IMP2872. Epub 2014 Oct 3. PubMed PMID: 25279606.
• Pellegrino P, Radice S, Clementi E. Geoepidemiology of acute disseminated encephalomyelitis. Epidemiology. 2014 Nov;25(6):928-9. doi: 10.1097/EDE.0000000000000176. PubMed PMID: 25265138.
• Degli Esposti L, Sangiorgi D, Perrone V, Radice S, Clementi E, Perone F, Buda S. Adherence and resource use among patients treated with biologic drugs: findings from BEETLE study. Clinicoecon Outcomes Res. 2014 Sep 18;6:401-7. doi: 10.2147/CEOR.S66338. eCollection 2014. PubMed PMID: 25258545; PubMed Central PMCID: PMC4171999.
• Pellegrino P, Clementi E, Capuano A, Radice S. Can vaccines interact with drug metabolism? Pharmacol Res. 2015 Feb;92:13-7. doi: 10.1016/j.phrs.2014.09.003. Epub 2014 Sep 26. Review. PubMed PMID: 25258293.
• Carnovale C, Pellegrino P, Perrone V, Gentili M, Brusadelli T, Antoniazzi S,  Speziali A, Borsadoli C, Pozzi M, Clementi E, Radice S. Establishing the correlation between statins and cough: case series report and analysis of adverse drug reactions in the international databases. Eur J Clin Pharmacol. 2014 Dec;70(12):1529-31. doi: 10.1007/s00228-014-1757-z. Epub 2014 Sep 24. PubMed PMID: 25245842.
• Provenzano G, Clementi E, Genovesi S, Scali M, Tripathi PP, Sgadò P, Bozzi Y. GH Dysfunction in Engrailed-2 Knockout Mice, a Model for Autism Spectrum Disorders. Front Pediatr. 2014 Sep 1;2:92. doi: 10.3389/fped.2014.00092. eCollection 2014. PubMed PMID: 25225635; PubMed Central PMCID: PMC4150208.
• Carnovale C, Brusadelli T, Zuccotti G, Beretta S, Sullo MG, Capuano A, Rossi  F, Moschini M, Mugelli A, Vannacci A, Laterza M, Clementi E, Radice S; MEAP Group. The importance of monitoring adverse drug reactions in pediatric patients: the results of a national surveillance program in Italy. Expert Opin Drug Saf. 2014 Sep;13 Suppl 1:S1-8. doi: 10.1517/14740338.2014.928692. PubMed PMID: 25171154.
• Baldelli S, Cattaneo D, Giodini L, Baietto L, Di Perri G, D'Avolio A, Clementi E. Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots. Clin Chem Lab Med. 2015 Feb;53(3):435-44. doi: 10.1515/cclm-2014-0472. PubMed PMID: 25153419.
• Pozzi M, Pellegrino P, Galbiati S, Granziera M, Locatelli F, Carnovale C, Perrone V, Antoniazzi S, Perrotta C, Strazzer S, Clementi E. Prevalence of respiratory colonisations and related antibiotic resistances among paediatric tracheostomised patients of a long-term rehabilitation centre in Italy. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):169-75. doi: 10.1007/s10096-014-2220-x. Epub 2014 Aug 9. PubMed PMID: 25107624.

Collaborazioni

• The Sanford-Burnham Medical Research Institute, San Diego, California, USA
• Department of Life and Health Science, University of Bordeaux Segalen, Bordeaux, France
• Dipartimento di Scienze Biochimiche e Cliniche, Ospedale Universitario L. Sacco, Università di Milano, Milano, Italia
• Centro Regionale di Farmacovigilanza e Farmacoepidemiologia della Campania, Napoli, Italia
• Centro Regionale di Farmacovigilanza e Farmacoepidemiologia della Lombardia, Milano, Italia
• Agenzia Italiana del Farmaco (AIFA), Roma, Italia
• Dipartimento di Scienze Mediche Traslazionali, Università Federico II di Napoli, Napoli, Italia
• Dipartimento di Salute Mentale e Fisica e Medicina Sperimentale, Università della Campania L. Vanvitellii, Napoli, Italia
• Dipartimento di Biomedicina Clinica e Molecolare, Università di Catania Istituto Veneto di Medicina Molecolare, Università di Padova, Padova, Italia